Short-term tests for chemical carcinogens

Publisher: Springer-Verlag in New York

Written in English
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  • Carcinogenicity testing -- Congresses.,
  • Carcinogens -- Congresses.,
  • Cocarcinogens -- Congresses.,
  • Carcinogens, Environmental -- Analysis -- Congresses.,
  • Biological assay -- Congresses.,
  • Mutagens -- Analysis -- Congresses.

Edition Notes

Includes bibliographies and index.

Statementedited by H.F. Stich, R.H.C. San.
SeriesTopics in environmental physiology and medicine
ContributionsStich, H. F. 1927-, San, R. H. C.
LC ClassificationsRC268.65 .S57
The Physical Object
Paginationxviii, 518 p. :
Number of Pages518
ID Numbers
Open LibraryOL4102039M
ISBN 100387904964
LC Control Number80016545

The effects of cannabis are caused by chemical compounds in the cannabis plant, including different cannabinoids such as tetrahydrocannabinol (THC), allow its drug to have various psychological and physiological effects on the human body. Different plants of the genus Cannabis contain different and often unpredictable concentrations of THC and other . Evaluation of short-term tests for carcinogens: A report of the international programme on chemical safety's collaborative study on in vivo assays By James E. Cleaver Topics: Book Author: James E. Cleaver. The following short term parameters evaluating essentially genotoxic effects were considered: liver DNA alkaline fragmentation (DFI), morphological transformation in hamster embryo cells (TPI), and mutagenicity in the Ames’ test (MPI). The internal consistency of the carcinogenicity data (OPI) was rather high (r = ). The correlation with OPI of DFI and MPI was statistically Cited by: 5. Short-Term Tests for Genetic Toxicity has been expanded with more complete Anonymous. () Chemical carcinogens: A review of the science and its associated principles. A report.

Red Book: Risk Assessment. Simple and indirect assay for potential carcinogens MEASURES frequency of back mutations with a histidine-independent parent strain. Short-term tests -Problem--reductionism Bioassays-Problem--interspecies extrapolation, choice of animals, route of exposure, dose-response. concerned with epidemiological guidelines, evaluation of short-term tests for carcinogens, biomarkers, effects on the elderly and so forth. Since its inauguration the EHC Programme has widened its scope, and the importance of environmental effects, in addition to health effects, has been increasingly emphasized in the total evaluation of chemicals. This Concise International Chemical Assessment Document (CICAD) is a compendium of evaluations of the scientific literature on the health and environmental effects of three glycol ethers: 2-methoxyethanol, 2-ethoxyethanol, 2-propoxyethanol and 2-butoxyethanol. Azo dyes are organic compounds bearing the functional group R−N=N−R′, in which R and R′ are usually are a commercially important family of azo compounds, i.e. compounds containing the linkage C-N=N-C. Azo dyes are widely used to treat textiles, leather articles, and some ally related to azo dyes are azo pigments, which are insoluble in water and .

Evaluation of Short-Term Tests for Carcinogens: Volume 2 avg rating — 0 ratings — published Want to Read saving. Risk Assessment is the process of determining the probability and magnitude of harm to human life, welfare and environment, potentially caused by the release of hazardous chemical, physical or biological pollutants. Assessment of risks is performed in four steps: 1. Hazard Identification 2. Toxicity Assessment 3. Exposure Assessment 4. Risk Characterisation. Step # 1. Hazard [ ]. methodology and discussion of the importance of using Short-Term Tests (STTs) as precautionary indicators of possible toxicological danger associated with potentially carcinogenic substances during the interim phase of toxicological risk assessments. An iterative approach to risk assessment supports the idea of initiallyAuthor: Timothy Riley. EPA has not classified the glycol ethers for carcinogenicity. Physical Properties The glycol ethers are colorless liquids with a slight odor. (1) The chemical formula for 2-methoxyethanol is C 3 H 8 O 2, and the molecular weight is g/mol. (4) The vapor pressure for 2-methoxyethanol is mm Hg at 25 °C, and it has a log octanol/water.

Short-term tests for chemical carcinogens Download PDF EPUB FB2

The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be­ tween the carcinogenicity and mutagenicity of chemicals and physical agents and by the assumption that DNA alteration, mutations, and chromosome aberrations are somehow involved in neoplastic transformation.

Short-term tests for chemical carcinogens. New York: Springer-Verlag, © (OCoLC) Online version: Short-term tests for chemical carcinogens.

New York: Springer-Verlag, © (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors / Contributors: H F Stich; R H C San.

Get this from a library. Short-Term Tests for Chemical Carcinogens. [H F Stich; R H C San] -- The recent surge of interest in designing, validating, and implementing short-term tests for carcinogens has been spurred by the fairly convincing correlation be­ tween the carcinogenicity and. @article{osti_, title = {Handbook of carcinogen testing}, author = {Milman, H.A.

and Weisburger, E.K.}, abstractNote = {This handbook of carcinogen testing outlines all methods, short- and long-term, of identifying chemical carcinogens.

By more than 60 international authorities, the book presents a view of bioassay - initial phases, application, attributes. The Use of Short- and Medium-term Tests for Carcinogens and Data on Genetic Effects in Carcinogenic Hazard Evaluation IARC Scientific Publication No.

Edited by McGregor DB, Rice JM, Venitt S. ISBN (Print Book) Formats Print Book. Other languages No other languages. Contact Us. Evaluation of short-term tests for carcinogens: Report of the International Programme on Chemical Safety's collaborative study on in vitro assays has chapter(s) DNA repair in human fibroblasts has chapter(s) Activity of 27 coded compounds in the RL1 chromosome assay has chapter(s) Mutagenic activity of 10 coded compounds.

growing opinionthat short-term tests can predict which chemicals may be car-cinogens. The third point is important because many short-term tests determine whether or not a chemical causes mutations (mutagenicity) rather than if it causes cancer (carcinogenicity).

The postulated relationship between mutagenicity. Short-term tests for carcinogens and mutagens Author links open overlay panel Monica Hollstein Joyce McCann Frank A. Angelosanto ∗ Warren W. Nichols ∗ Show moreCited by: Short-term tests for chemical carcinogens book International Program on Chemical Safety.

Guide to short-term tests for detecting mutagenic and carcinogenic chemicals / prepared for the IPCS by the International Commission for Protection Against Environmental Mutagens and Carcinogens World Health Organization ; WHO Publications Center USA [distributor] Geneva: Albany, NY.

The chemicals were classified into carcinogens (58) and non-carcinogens (62) on the basis of published experimental data, and into 1 of 4 broad chemical classes. There was considerable variation between tests in their ability to predict carcinogenicity, with the cell-transformation test and the bacterial-mutation test being the most accurate Cited by: INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY ENVIRONMENTAL HEALTH CRITERIA 51 GUIDE TO SHORT-TERM TESTS FOR DETECTING MUTAGENIC AND CARCINOGENIC CHEMICALS Prepared for the IPCS by the International Commission for Protection Against Environmental Mutagens and Carcinogens This report contains the.

Short-term tests have been singled out for intensive research and development because they are potentially valuable tools for achieving this goal. Many types of short-term tests are being developed, but this document has focused on short-term tests that attempt to detect a chemical's potential to cause cancer and genetic dis- ease.

ICH Guidelines S1A, S1B and S1C on carcinogenicity testing stipulate one long-term test in a rodent species (usually rat), plus one other in vivo test, which may be either (a) a short-term test designed to show high sensitivity to carcinogens (e.g. transgenic mouse models) or to detect early events associated with tumour initiation or promotion.

Book review supplement | Volume 4, P95, Janu PDF [ KB] Download PDF [ KB] Save. Add to Online Library Powered By Mendeley; Short-term tests for chemical carcinogens. Previous Article Side effects of drugs annual 6.

Next Article Hormone receptors. Article Info by: 1. It is reaction with nucleic acids that provides the basis of a num­ ber of short-term tests for carcinogens, since the basic composition of DNA is similar in.

Book/Book Chapter Title. Progress in Mutation Research: Volume 5. Evaluation of short-term tests for carcinogens: Report of the International Programme on Chemical Safety's collaborative study on in vitro assays Year.

Publisher. Elsevier Location. Amsterdam, Netherlands. Abstract. At least 30 short-term tests for chemical carcinogens have been described during the past few years (Anon., ). They range from bacterial DNA repair assays in vitro through to several mammalian tests conducted in l of these tests, such as the Salmonella reverse mutation assay developed by Ames et al.

(), have been used extensively and Cited by: 3. INTERNATIONAL PROGRAMME ON CHEMICAL SAFETY ENVIRONMENTAL HEALTH CRITERIA SUMMARY REPORT ON THE EVALUATION OF SHORT-TERM TESTS FOR CARCINOGENS (COLLABORATIVE STUDY ON IN VIVO TESTS) This report contains the collective views of an international group of experts and does not necessarily represent the.

Swenberg J.A. () Utilization of the Alkaline Elution Assay as a Short-Term Test for Chemical Carcinogens. In: Stich H.F., San R.H.C. (eds) Short-Term Tests for Chemical Carcinogens. Topics in Environmental Physiology and by: @article{osti_, title = {Review of short-term screening tests for mutagens, toxigens, and carcinogens}, author = {Carney, H.

and Hass, B. S.}, abstractNote = {In order to test the thousands of man-made chemicals in the environment for carcinogenic and genetic hazards, a multitude of short-term screening tests has been developed to complement long-term. : Evaluation Short-Term Tests for Carcinogens. Report of the International Collaborative Program.

Progress in Mutation Research, Volume 1 (): Frederick J. de Serres, John Ashby: Books. Buy Short-Term Tests for Chemical Carcinogens (Topics in Environmental Physiology and Medicine) Softcover reprint of the original 1st ed.

by H.F. Stich (ISBN: ) from Amazon's Book Store. Everyday low prices and free delivery on eligible : H.F. Stich. Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF. Visit to get more information about this book, to buy it in print, or to download it as a free PDF.

Below is the uncorrected machine-read text. NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.L. Bernstein, and Short-term tests for carcinogens and mutagens: A data base designed for comparative quantitative Evaluation of six short-term tests for detecting organic chemical carcinogens and.

She argued that short-term tests are valid experimental predictors of chemical carcin' genesis for four reasons: (~) although no test detects care inogens, most carcinogens are detected in a relatively few mutagenicity tests; (2) although some carcinogens are not detected in any test, a combination of tests increases the proportion of.

Strategies For Short Term Test For Mutagens Carcinogens (CRC toxicology series): Medicine & Health Science Books @ of the importance of metabolism of carcinogens to active agents suggested a close relationship between mutagens and carcinogens, and is the basis of many short-term tests (particularly the Ames bacterial test) being used as indicator of chemicals that may also be carcinogenic.

Substances active in such tests are termed 'genotoxic'.File Size: 95KB. Short-Term Tests: Transformation Assays. Chronic Testing for Carcinogenicity. Chronic (Two Year) Bioassay. Organ-Specific Bioassays and Multistage Animal Models. Transgenic Animals in Carcinogenicity Assessment. New Approaches.

Chemical Carcinogenesis in Humans. Classification Evaluation of Carcinogenicity in Humans. Summary + +. Marijuana main active chemical.

THC, Marijuana and the lungs. TAR in Marijuana. 4x higher than tobacco. Marijuana short term effects. Dry mouth, Increased heart rate, anxiety, loss of motor coordination, trouble problem solving, memory and learning, and distorted perception.

solvent effects on tobacco or other carcinogens, induction of. book about exposures to chemical carcinogens and cancer. short-term tests, it may also be worthwhile to consider Environmental Carcinogens and Mutagens.


R Project Officer Al W. Bourquin Environmental Research Laboratory Gulf Breeze, Florida .These short-term tests are based on the premise that carcinogens are agents capable of damaging DNA, but as it is recognized that not all carcinogens are mutagens and/or not.

and developing various short-term tests of cocarcinogenic activity. (Book review) Nature Bridges. B.A. Short term screening test for carcinogens Mutagenesis and transformation of normal cells by chemical carcinogens. Nature. Google Scholar. Crossref. Search ADS. PubMed Kahn Cited by: